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The Brasch and Sampson research groups were recently awarded a 3-year $400,000 grant from the National Science Foundation.
The Brasch and Sampson research groups were recently awarded a 3-year $400,000 grant from the National Science Foundation.
Summer 2013 REU students in Chemistry and the Liquid Crystal Institute.
Summer 2013 REU students in Chemistry and the Liquid Crystal Institute.
Chemistry faculty talk to undergraduate students at the Blastoff event
Chemistry faculty talk to undergraduate students at the Blastoff event
Students watch a thermite reaction take place in front of Williams Hall.
Students watch a thermite reaction take place in front of Williams Hall.
One of the very first chemistry labs at Kent State University.
One of the very first chemistry labs at Kent State University.
Williams Hall, home of the Department of Chemistry and Biochemistry
Williams Hall, home of the Department of Chemistry and Biochemistry
An undergraduate student paints a structure on the wall of a research lab.
An undergraduate student paints a structure on the wall of a research lab.

Department of Chemistry & Biochemistry

Welcome to the Department of Chemistry and Biochemistry at Kent State University.  We invite you to browse these pages that describe our instructional and research community.  Here you will find award-winning teachers, internationally recognized scholars, excellent research facilities, and active researchers creating new materials and new knowledge.  Read about our course and degree offerings, and explore our photo and video galleries.

Our graduates can be found in local industry as well as Fortune 500 firms across the United States.  Many of our undergraduate students pursue graduate education in chemistry or biochemistry; others complete professional training in medicine, dentistry, or pharmacy.  Our Ph.D. alumni are researching and teaching at prestigious companies, colleges, and universities around the world.  Have you been part of the Kent State Chemistry and Biochemistry community?  If you're an alumnus of our Department, please take a moment to let us know what you are doing now.

Our alumni do great things every day - we invite YOU to become part of our success story!

 

Research Highlight

Role of Mysterious Folded DNA Structures Revealed at Last

Research highlight image

Yunxi Cui, Deepak Koirala, HyunJin Kang, Soma Dhakal, Philip Yangyuoru, Laurence H. Horley and Hanbin Mao*

Nucleic Acids Research 2014

Abstract:
A cytosine-rich oncogene promoter sequence (bcl-2) has been observed to form i-motif and hairpin structures, which are non-canonical DNA structures different from the DNA duplex.  Since these structures regulate gene expressions, especially those for cancer genes, the analysis of the equilibrium among different structures in oncogene promoter regions attracts great interest.  Using mechanical unfolding in laser tweezers, we introduced a new method, molecular population dynamics (MPD), to examine not only this equilibrium, but also the influence of small molecules and a transcription factor (hnRNP LL) on the equilibrium.  We observed a total of six different DNA structures in the bcl-2 promoter.  The equilibrium of these species is regulated by a piperidine derivative (IMC-48), a pregnanol derivative (IMC-76), and the transcription factor, hnRNP LL.  These results indicate the existence of a DNA switch mechanism similar to that observed in the riboswitch.


Research Highlight Archive

Department of Chemistry and Biochemistry · Williams Hall · (330) 672-2032

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